Located at the top of the kidneys, your adrenal glands are responsible for producing certain hormones that are used for proper functioning of almost every organ in your body. Although rare, adrenal cancer can occur in the layers of the adrenal gland called the adrenal cortex. Symptoms may include muscle weakness, weight gain, hormonal changes, nausea, fevers and vomiting. Your doctor may order blood tests, radiography tests, and urinalysis to determine if you have adrenal cancer. Treatment may include surgery, radiation or chemotherapy. Genetic screening is often done to determine how aggressive adrenal cancers can be.